| 2021-10-18 | Moscow | Hard | R16 | 108 |  Ricardas Berankis (LL) | 68 |  Federico Coria | 6-2 6-1 | H2H | 3 | 68 | 1 | 1 | 57.1% | 79.2% | 66.7% | 4/4 |
| 2021-10-18 | Moscow | Hard | R32 | 68 | Federico Coria | 638 |  Alibek Kachmazov (WC) | 6-2 5-7 6-2 | H2H | 3 | 131 | 1 | 2 | 69.6% | 59.2% | 67.7% | 11/14 |
| 2021-10-04 | Indian Wells Masters | Hard | R128 | 83 |  Brandon Nakashima | 67 | Federico Coria | 6-3 6-2 | H2H | 3 | 78 | 1 | 0 | 52.7% | 79.3% | 61.5% | 1/1 |
| 2021-09-18 | Davis Cup WG1 R1: ARG vs BLR | Clay | RR | 61 | Federico Coria | - |  Daniil Ostapenkov | 6-3 6-1 | H2H | 3 | 66 | 4 | 2 | 64.0% | 78.1% | 50.0% | 0/1 |
| 2021-08-30 | US Open | Hard | R128 | 20 |  Gael Monfils (17) | 62 | Federico Coria | 6-3 6-2 6-2 | H2H | 5 | 94 | 8 | 3 | 59.4% | 92.7% | 50.0% | 1/2 |
| 2021-08-23 | Winston-Salem | Hard | R32 | 104 | Pierre-Hugues Herbert (LL) | 61 | Federico Coria | 6-4 6-2 | H2H | 3 | 74 | 3 | 1 | 64.2% | 82.4% | 63.2% | 3/3 |
| 2021-08-23 | Winston-Salem | Hard | R64 | 61 | Federico Coria | 58 |  Lorenzo Musetti | 6-4 4-6 6-4 | H2H | 3 | 164 | 4 | 11 | 61.6% | 68.1% | 39.5% | 7/12 |
| 2021-07-24 | Tokyo Olympics | Hard | R64 | 123 |  Mikhail Kukushkin | 62 | Federico Coria | 7-6(4) 7-5 | H2H | 3 | - | - | - | - | - | - | - |
| 2021-07-12 | Bastad | Clay | SF | 77 | Federico Coria | 107 |  Yannick Hanfmann | 6-2 6-1 | H2H | 3 | 71 | 2 | 1 | 66.7% | 76.9% | 69.2% | 0/0 |
| 2021-07-12 | Bastad | Clay | QF | 77 | Federico Coria | 18 |  Cristian Garin (2) | 6-4 4-6 6-2 | H2H | 3 | 154 | 3 | 4 | 62.9% | 65.6% | 50.0% | 5/9 |
