| 2012-08-27 | US Open | Hard | R128 | 26 |  Fernando Verdasco (25) | 131 |  Rui Machado | 6-1 6-2 6-4 | H2H | 5 | 100 | 6 | 4 | 60.6% | 76.7% | 64.3% | 2/3 |
| 2012-06-25 | Wimbledon | Grass | R128 | 126 |  Brian Baker (Q) | 96 | Rui Machado | 7-6(2) 6-4 6-0 | H2H | 5 | 114 | 6 | 6 | 51.8% | 86.0% | 62.5% | 1/2 |
| 2012-05-27 | Roland Garros | Clay | R128 | 34 |  Kevin Anderson (31) | 80 | Rui Machado | 7-6(2) 6-7(6) 4-6 6-1 11-9 | H2H | 5 | 290 | 26 | 7 | 67.2% | 71.4% | 56.9% | 11/15 |
| 2012-04-30 | Estoril | Clay | R16 | 12 |  Juan Martin del Potro (1) | 90 | Rui Machado | 6-1 6-0 | H2H | 3 | 62 | 4 | 1 | 58.1% | 88.0% | 50.0% | 2/2 |
| 2012-04-30 | Estoril | Clay | R32 | 90 | Rui Machado | 244 | Pedro Sousa (WC) | 6-7(3) 6-1 6-2 | H2H | 3 | 122 | 2 | 8 | 66.3% | 67.7% | 48.5% | 2/4 |
| 2012-04-23 | Barcelona | Clay | R64 | 102 |  Victor Hanescu | 92 | Rui Machado | 6-3 7-6(5) | H2H | 3 | 121 | 3 | 0 | 68.9% | 66.1% | 46.4% | 9/11 |
| 2012-04-09 | Casablanca | Clay | R32 | 544 | Sergio Gutierrez-Ferrol (Q) | 97 | Rui Machado | 6-2 6-1 | H2H | 3 | 71 | 5 | 2 | 45.2% | 67.9% | 55.9% | 5/6 |
| 2012-04-06 | Davis Cup G1 R2: ISR vs POR | Hard | RR | 199 |  Amir Weintraub | 101 | Rui Machado | 5-7 6-3 6-1 7-5 | H2H | 5 | - | - | - | - | - | - | - |
| 2012-03-08 | Indian Wells Masters | Hard | R128 | 92 | Guillermo Garcia-Lopez | 83 | Rui Machado | 7-6(6) 4-6 6-2 | H2H | 3 | 156 | 5 | 4 | 53.6% | 67.3% | 51.1% | 1/5 |
| 2012-02-27 | Acapulco | Clay | R32 | 64 |  Jeremy Chardy | 79 | Rui Machado | 7-6(4) 6-3 | H2H | 3 | 120 | 4 | 6 | 50.0% | 72.1% | 46.5% | 6/8 |
