| 2021-11-25 | Davis Cup Finals RR: FRA vs CZE | Hard | RR | 71 |  Adrian Mannarino | 82 |  Jiri Vesely | 6-7(1) 6-4 6-2 | H2H | 3 | 152 | 0 | 3 | 62.1% | 78.1% | 43.6% | 2/3 |
| 2021-11-27 | Davis Cup Finals RR: FRA vs GBR | Hard | RR | 25 |  Daniel Evans | 71 | Adrian Mannarino | 7-5 6-4 | H2H | 3 | 114 | 2 | 3 | 69.2% | 71.1% | 65.0% | 1/2 |
| 2021-11-08 | Stockholm | Hard | R32 | 40 |  Marton Fucsovics (7) | 66 | Adrian Mannarino | 6-4 6-0 | H2H | 3 | 72 | 6 | 0 | 69.8% | 86.7% | 61.5% | 1/1 |
| 2021-11-01 | Paris Masters | Hard | R32 | 22 | Gael Monfils (15) | 59 | Adrian Mannarino | 2-6 7-6(4) 6-2 | H2H | 3 | 146 | 9 | 3 | 62.2% | 66.1% | 55.9% | 4/8 |
| 2021-11-01 | Paris Masters | Hard | R64 | 59 | Adrian Mannarino | 21 |  Nikoloz Basilashvili | 6-2 6-4 | H2H | 3 | 75 | 3 | 0 | 57.1% | 82.1% | 42.9% | 3/5 |
| 2021-10-25 | St. Petersburg | Hard | R32 | 30 |  Karen Khachanov (6) | 50 | Adrian Mannarino | 6-3 6-3 | H2H | 3 | 85 | 5 | 0 | 53.5% | 82.6% | 85.0% | 0/0 |
| 2021-10-18 | Moscow | Hard | QF | 108 |  Ricardas Berankis (LL) | 51 | Adrian Mannarino | 6-2 7-6(1) | H2H | 3 | 116 | 1 | 2 | 60.8% | 68.8% | 58.1% | 7/8 |
| 2021-10-18 | Moscow | Hard | R16 | 51 | Adrian Mannarino | 6 | Andrey Rublev (1) | 5-7 7-6(4) 6-3 | H2H | 3 | 149 | 9 | 2 | 67.3% | 72.2% | 54.3% | 3/7 |
| 2021-10-18 | Moscow | Hard | R32 | 51 | Adrian Mannarino | 160 | Roman Safiullin (WC) | 1-6 7-6(6) 6-4 | H2H | 3 | 151 | 7 | 3 | 65.3% | 67.7% | 42.4% | 6/10 |
| 2021-10-04 | Indian Wells Masters | Hard | R128 | 121 | Andy Murray (WC) | 51 | Adrian Mannarino | 6-3 6-2 | H2H | 3 | 83 | 5 | 3 | 51.9% | 82.1% | 61.5% | 1/1 |
