| 2022-09-14 | Davis Cup Finals RR: FRA vs GER | Hard | RR | 132 |  Jan-Lennard Struff | 53 |  Benjamin Bonzi | 6-4 2-6 7-5 | H2H | 3 | - | - | - | - | - | - | - |
| 2022-11-24 | Davis Cup Finals QF: GER vs CAN | Hard | RR | 152 | Jan-Lennard Struff | 18 |  Denis Shapovalov | 6-3 4-6 7-6(2) | H2H | 3 | - | - | - | - | - | - | - |
| 2022-09-26 | Sofia | Hard | QF | 30 |  Lorenzo Musetti (4) | 133 | Jan-Lennard Struff (Q) | 7-6(3) 6-1 | H2H | 3 | 75 | 9 | 2 | 65.5% | 86.1% | 57.9% | 1/2 |
| 2022-09-26 | Sofia | Hard | R16 | 133 | Jan-Lennard Struff (Q) | 110 | Ugo Humbert (Q) | 6-3 6-1 | H2H | 3 | 61 | 6 | 1 | 53.7% | 95.5% | 57.9% | 0/0 |
| 2022-09-26 | Sofia | Hard | R32 | 133 | Jan-Lennard Struff (Q) | 86 |  Dusan Lajovic | 4-6 6-3 6-2 | H2H | 3 | 100 | 14 | 5 | 62.3% | 89.6% | 41.4% | 5/7 |
| 2022-09-18 | Davis Cup Finals RR: GER vs AUS | Hard | RR | 132 | Jan-Lennard Struff | 233 |  Max Purcell | 6-1 7-5 | H2H | 3 | - | - | - | - | - | - | - |
| 2022-09-16 | Davis Cup Finals RR: GER vs BEL | Hard | RR | 132 | Jan-Lennard Struff | 134 |  Zizou Bergs | 6-4 7-6(9) | H2H | 3 | - | - | - | - | - | - | - |
| 2022-07-18 | Hamburg | Clay | R32 | 26 |  Karen Khachanov (7) | 122 | Jan-Lennard Struff (WC) | 3-6 6-3 7-6(2) | H2H | 3 | 136 | 11 | 4 | 66.4% | 71.2% | 45.9% | 12/15 |
| 2022-06-27 | Wimbledon | Grass | R128 | 7 |  Carlos Alcaraz (5) | 155 | Jan-Lennard Struff | 4-6 7-5 4-6 7-6(3) 6-4 | H2H | 5 | 251 | 30 | 7 | 65.3% | 75.7% | 55.9% | 6/8 |
| 2022-06-13 | Halle | Grass | R32 | 42 |  Ilya Ivashka | 149 | Jan-Lennard Struff (WC) | 3-6 6-3 7-6(5) | H2H | 3 | 123 | 9 | 4 | 69.3% | 72.9% | 51.6% | 3/5 |
