| 2020-03-06 | Davis Cup QLS R1: ARG vs COL | Clay | RR | 62 |  Juan Ignacio Londero | 292 |  Santiago Giraldo | 6-7(6) 6-3 6-2 | H2H | 3 | 138 | 5 | 6 | 58.5% | 83.3% | 50.0% | 2/4 |
| 2019-11-18 | Davis Cup Finals RR: BEL vs COL | Hard | RR | 158 |  Steve Darcis | 277 | Santiago Giraldo | 6-3 6-2 | H2H | 3 | 64 | 0 | 2 | 66.7% | 61.1% | 38.9% | 2/5 |
| 2019-08-26 | US Open | Hard | R128 | 75 |  Alexander Bublik | 232 | Santiago Giraldo | 2-6 6-0 7-5 3-6 6-4 | H2H | 5 | 194 | 21 | 19 | 51.6% | 72.2% | 44.6% | 8/15 |
| 2019-04-08 | Houston | Clay | R16 | 67 |  Jordan Thompson (7) | 224 | Santiago Giraldo (Q) | 4-6 7-6(1) 7-5 | H2H | 3 | 173 | 6 | 3 | 61.2% | 77.8% | 45.0% | 5/9 |
| 2019-04-08 | Houston | Clay | R32 | 224 | Santiago Giraldo (Q) | 93 |  Bradley Klahn | 6-4 6-4 | H2H | 3 | 89 | 2 | 1 | 80.3% | 77.6% | 58.3% | 4/4 |
| 2019-02-01 | Davis Cup QLS R1: SWE vs COL | Clay | RR | 251 | Santiago Giraldo | 116 |  Elias Ymer | 6-2 6-4 | H2H | 3 | 72 | 5 | 5 | 64.5% | 77.5% | 40.9% | 2/3 |
| 2018-09-14 | Davis Cup WG PO: ARG vs COL | Clay | RR | 14 | Diego Schwartzman | 410 | Santiago Giraldo | 6-3 6-1 6-7(3) 6-1 | H2H | 5 | 163 | 4 | 2 | 67.2% | 67.5% | 46.2% | 6/10 |
| 2018-05-28 | Roland Garros | Clay | R64 | 13 |  Roberto Bautista Agut (13) | 315 | Santiago Giraldo | 6-4 7-5 6-3 | H2H | 5 | 127 | 3 | 1 | 50.6% | 79.5% | 55.8% | 3/5 |
| 2018-05-28 | Roland Garros | Clay | R128 | 315 | Santiago Giraldo | 84 |  Marcos Baghdatis | 3-6 3-4 RET | H2H | 5 | 78 | 3 | 0 | 62.5% | 70.0% | 55.6% | 2/4 |
| 2018-04-06 | Davis Cup G1 R2: COL vs BRA | Hard | RR | 125 |  Thiago Monteiro | 290 | Santiago Giraldo | 6-1 6-2 | H2H | 3 | 59 | 4 | 2 | 69.2% | 83.3% | 43.8% | 3/3 |
