| 2024-10-02 | Shanghai Masters | Hard | R128 | 62 |  Arthur Rinderknech | 309 |  Reilly Opelka (PR) | 6-4 7-6(5) | H2H | 3 | 112 | 6 | 0 | 71.8% | 78.4% | 60.0% | 1/1 |
| 2024-09-25 | Tokyo | Hard | R32 | 17 | Ben Shelton (8) | 307 | Reilly Opelka (PR) | 3-6 6-1 6-4 | H2H | 3 | 106 | 8 | 3 | 72.2% | 76.9% | 50.0% | 3/5 |
| 2024-09-11 | Davis Cup Finals RR: USA vs CHI | Hard | RR | 309 | Reilly Opelka | 116 |  Cristian Garin | 6-3 4-6 7-6(3) | H2H | 3 | 146 | 27 | 4 | 69.4% | 77.9% | 46.7% | 4/5 |
| 2024-09-14 | Davis Cup Finals RR: GER vs USA | Hard | RR | 309 | Reilly Opelka | 187 |  Henri Squire | 6-7(4) 7-6(9) 6-3 | H2H | 3 | 142 | 33 | 1 | 72.2% | 87.1% | 81.5% | 2/2 |
| 2024-08-26 | US Open | Hard | R128 | 18 |  Lorenzo Musetti (18) | 324 | Reilly Opelka | 7-6(3) 1-6 6-1 7-5 | H2H | 5 | 174 | 7 | 6 | 50.0% | 75.4% | 63.2% | 3/6 |
| 2024-08-18 | Winston-Salem | Hard | R64 | 85 |  Zizou Bergs | 322 | Reilly Opelka (WC) | 6-4 3-6 7-6(1) | H2H | 3 | 140 | 6 | 4 | 66.3% | 73.8% | 71.0% | 3/4 |
| 2024-08-12 | Cincinnati Masters | Hard | R64 | 14 | Ben Shelton (12) | 322 | Reilly Opelka (WC) | 7-6(3) 7-6(3) | H2H | 3 | 98 | 6 | 4 | 69.9% | 91.4% | 48.0% | 5/5 |
| 2024-07-29 | Washington | Hard | R32 | 33 |  Jordan Thompson (7) | 371 | Reilly Opelka (WC) | 6-4 6-3 | H2H | 3 | 80 | 1 | 1 | 64.7% | 72.7% | 61.1% | 4/5 |
| 2024-07-29 | Washington | Hard | R64 | 371 | Reilly Opelka (WC) | 81 | James Duckworth | 6-7(12) 7-5 6-4 | H2H | 3 | 141 | 27 | 0 | 59.6% | 83.1% | 70.0% | 0/0 |
| 2024-07-22 | Atlanta | Hard | R16 | 43 |  Alejandro Davidovich Fokina (5) | 430 | Reilly Opelka (SE) | 7-5 7-5 | H2H | 3 | 106 | 3 | 1 | 73.3% | 74.5% | 70.0% | 4/4 |
