| 2022-11-24 | Davis Cup Finals QF: ITA vs USA | Hard | RR | 45 |  Lorenzo Sonego | 19 |  Frances Tiafoe | 6-3 7-6(7) | H2H | 3 | - | - | - | - | - | - | - |
| 2022-10-31 | Paris Masters | Hard | QF | 8 |  Felix Auger-Aliassime (8) | 21 | Frances Tiafoe (16) | 6-1 6-4 | H2H | 3 | 93 | 8 | 0 | 72.0% | 86.1% | 50.0% | 0/0 |
| 2022-10-31 | Paris Masters | Hard | R16 | 21 | Frances Tiafoe (16) | 25 |  Alex de Minaur | 6-3 7-6(5) | H2H | 3 | 100 | 14 | 3 | 58.4% | 73.3% | 53.1% | 4/5 |
| 2022-10-31 | Paris Masters | Hard | R32 | 21 | Frances Tiafoe (16) | 45 |  Jack Draper | 6-3 7-5 | H2H | 3 | 84 | 7 | 1 | 60.0% | 81.0% | 53.6% | 7/7 |
| 2022-10-31 | Paris Masters | Hard | R64 | 21 | Frances Tiafoe (16) | 51 | Lorenzo Sonego (Q) | 6-4 6-4 | H2H | 3 | 74 | 3 | 0 | 65.3% | 84.4% | 76.5% | 0/0 |
| 2022-10-24 | Vienna | Hard | R32 | 11 |  Hubert Hurkacz (5) | 17 | Frances Tiafoe | 7-6(9) 3-6 6-3 | H2H | 3 | 142 | 28 | 3 | 64.3% | 84.1% | 45.7% | 3/5 |
| 2022-10-17 | Stockholm | Hard | QF | 52 |  Emil Ruusuvuori | 17 | Frances Tiafoe (3) | 6-1 6-2 | H2H | 3 | 64 | 7 | 1 | 65.9% | 96.3% | 50.0% | 0/0 |
| 2022-10-17 | Stockholm | Hard | R16 | 17 | Frances Tiafoe (3) | 129 |  Elias Ymer (WC) | 3-6 7-6(4) 7-6(2) | H2H | 3 | 156 | 11 | 3 | 57.9% | 79.0% | 44.4% | 4/7 |
| 2022-10-03 | Tokyo | Hard | F | 11 | Taylor Fritz (3) | 19 | Frances Tiafoe (4) | 7-6(3) 7-6(2) | H2H | 3 | 116 | 12 | 0 | 67.6% | 78.0% | 75.0% | 2/3 |
| 2022-10-03 | Tokyo | Hard | SF | 19 | Frances Tiafoe (4) | 120 |  Soonwoo Kwon | 6-2 0-6 6-4 | H2H | 3 | 96 | 9 | 2 | 52.7% | 69.2% | 45.7% | 4/8 |
