| R64 | 69 |  Pedro CachinClay | 121 |  Gijs BrouwerClay | 6-3 7-5 | 3 | 78 | 4 | 1 | 58.8% | 80.0% | 53.6% | 4/5 |
| R64 | 155 |  Jozef KovalikClay | 136 |  Pedro MartinezClay | 7-5 2-6 7-5 | 3 | 171 | 3 | 2 | 59.4% | 54.0% | 51.2% | 9/16 |
| R64 | 120 |  Emilio GomezClay | 58 | Albert Ramos-VinolasClay | 6-3 1-6 6-4 | 3 | 120 | 2 | 4 | 63.8% | 63.6% | 36.0% | 3/9 |
| R64 | 98 |  Alexander ShevchenkoClay | 223 |  Lorenzo GiustinoClay | 6-2 6-2 | 3 | 63 | 6 | 1 | 55.8% | 83.3% | 63.2% | 0/0 |
| R64 | 48 | Diego SchwartzmanClay | 56 |  Yibing WuClay | 6-2 6-2 | 3 | 79 | 0 | 0 | 66.7% | 60.7% | 85.7% | 1/2 |
| R64 | 99 |  David GoffinClay | 593 | Feliciano LopezClay | 7-6(3) 6-7(4) 6-0 | 3 | 135 | 8 | 5 | 63.0% | 82.4% | 56.7% | 0/3 |
| R64 | 66 |  Jason KublerClay | 300 | Daniel RinconClay | 6-4 6-3 | 3 | 81 | 2 | 2 | 74.5% | 76.3% | 69.2% | 0/1 |
| R64 | 108 |  Pavel KotovClay | 180 |  Oleksii KrutykhClay | 6-7(5) 6-4 6-1 | 3 | 145 | 6 | 3 | 75.3% | 80.3% | 70.0% | 1/1 |
| R64 | 51 |  Nicolas JarryClay | 240 | Marco TrungellitiClay | 7-5 6-3 | 3 | 110 | 5 | 4 | 49.2% | 78.1% | 57.6% | 1/2 |
| R64 | 105 | Matteo ArnaldiClay | 83 | Jaume MunarClay | 6-3 6-4 | 3 | 117 | 1 | 1 | 50.0% | 66.7% | 46.2% | 8/11 |
| R64 | 125 | Francesco PassaroClay | 244 | Fernando VerdascoClay | 6-1 6-1 | 3 | 62 | 3 | 2 | 53.8% | 85.7% | 44.4% | 1/2 |
| R64 | 37 |  Ben SheltonClay | 54 | Mackenzie McDonaldClay | 7-5 6-4 | 3 | 98 | 9 | 2 | 72.1% | 67.3% | 42.1% | 1/4 |
| R64 | 40 |  Emil RuusuvuoriClay | 55 | Alexander BublikClay | 6-0 6-3 | 3 | 55 | 0 | 1 | 61.7% | 75.9% | 66.7% | 1/1 |
| R64 | 59 | Tomas Martin EtcheverryClay | 323 | Pablo AndujarClay | 6-2 7-5 | 3 | 120 | 3 | 4 | 71.8% | 60.7% | 40.9% | 9/12 |
| R64 | 41 | Bernabe Zapata MirallesClay | 745 |  Attila BalazsClay | 6-2 6-2 | 3 | 74 | 0 | 1 | 63.5% | 66.7% | 42.1% | 1/3 |
| R64 | 79 |  Nuno BorgesClay | 61 |  Ilya IvashkaClay | 6-2 6-3 | 3 | 85 | 2 | 0 | 66.0% | 64.5% | 75.0% | 0/2 |
| R32 | 5 |  Stefanos TsitsipasClay | 69 | Pedro CachinClay | 6-4 6-2 | 3 | 78 | 1 | 0 | 63.0% | 85.3% | 50.0% | 0/0 |
| R32 | 28 |  Denis ShapovalovClay | 155 | Jozef KovalikClay | 6-4 6-3 | 3 | 80 | 13 | 4 | 66.2% | 75.6% | 47.8% | 7/7 |
| R32 | 31 |  Grigor DimitrovClay | 120 | Emilio GomezClay | 6-3 6-1 | 3 | 63 | 6 | 2 | 64.3% | 92.6% | 40.0% | 0/1 |
| R32 | 19 | Alex de MinaurClay | 98 | Alexander ShevchenkoClay | 6-0 6-1 | 3 | 62 | 0 | 1 | 45.0% | 88.9% | 54.5% | 3/3 |
| R32 | 8 | Jannik SinnerClay | 48 | Diego SchwartzmanClay | 6-2 6-4 | 3 | 100 | 1 | 2 | 60.0% | 55.6% | 66.7% | 5/8 |
| R32 | 35 |  Yoshihito NishiokaClay | 99 | David GoffinClay | 6-1 7-5 | 3 | 75 | 3 | 1 | 66.0% | 66.7% | 76.5% | 1/3 |
| R32 | 20 | Lorenzo MusettiClay | 66 | Jason KublerClay | 6-3 6-1 | 3 | 73 | 2 | 0 | 63.8% | 70.0% | 58.8% | 1/2 |
| R32 | 13 |  Cameron NorrieClay | 108 | Pavel KotovClay | 6-1 6-2 | 3 | 73 | 2 | 2 | 67.3% | 71.4% | 70.6% | 4/4 |
| R32 | 11 | Karen KhachanovClay | 51 | Nicolas JarryClay | 6-4 6-4 | 3 | 94 | 2 | 1 | 65.0% | 69.2% | 61.9% | 3/4 |
| R32 | 26 | Daniel EvansClay | 105 | Matteo ArnaldiClay | 6-4 6-3 | 3 | 108 | 4 | 1 | 66.2% | 70.2% | 54.2% | 10/10 |
| R32 | 32 | Francisco CerundoloClay | 125 | Francesco PassaroClay | 6-2 6-2 | 3 | 71 | 0 | 3 | 73.1% | 84.2% | 35.7% | 3/3 |
| R32 | 3 |  Casper RuudClay | 37 | Ben SheltonClay | 6-2 7-6(1) | 3 | 99 | 0 | 2 | 73.9% | 76.5% | 44.4% | 4/5 |
| R32 | 40 | Emil RuusuvuoriClay | 12 | Frances TiafoeClay | 6-4 6-7(3) 6-4 | 3 | 165 | 11 | 4 | 70.8% | 64.7% | 45.7% | 13/17 |
| R32 | 38 | Alejandro Davidovich FokinaClay | 59 | Tomas Martin EtcheverryClay | 6-3 6-3 | 3 | 91 | 0 | 2 | 71.7% | 76.3% | 40.0% | 2/3 |
| R32 | 25 | Roberto Bautista AgutClay | 41 | Bernabe Zapata MirallesClay | 6-2 6-2 | 3 | 61 | 1 | 0 | 58.1% | 76.0% | 66.7% | 1/2 |
| R32 | 2 | Carlos AlcarazClay | 79 | Nuno BorgesClay | 6-3 6-1 | 3 | 63 | 0 | 2 | 48.8% | 76.2% | 68.2% | 1/2 |
| R16 | 5 | Stefanos TsitsipasClay | 28 | Denis ShapovalovClay | 6-3 6-2 | 3 | 77 | 1 | 3 | 66.1% | 73.0% | 63.2% | 2/2 |
| R16 | 19 | Alex de MinaurClay | 31 | Grigor DimitrovClay | W/O | 3 | 0 | - | - | - | - | - | - |
| R16 | 8 | Jannik SinnerClay | 35 | Yoshihito NishiokaClay | 6-1 4-6 6-3 | 3 | 128 | 4 | 2 | 43.8% | 75.0% | 46.3% | 4/9 |
| R16 | 20 | Lorenzo MusettiClay | 13 | Cameron NorrieClay | 3-6 6-4 6-1 | 3 | 124 | 1 | 1 | 70.3% | 62.5% | 55.6% | 6/8 |
| R16 | 26 | Daniel EvansClay | 11 | Karen KhachanovClay | 6-3 6-4 | 3 | 88 | 5 | 1 | 66.2% | 73.3% | 60.9% | 5/5 |
| R16 | 32 | Francisco CerundoloClay | 3 | Casper RuudClay | 7-6(5) 6-3 | 3 | 113 | 1 | 5 | 69.6% | 76.4% | 41.7% | 3/4 |
| R16 | 38 | Alejandro Davidovich FokinaClay | 40 | Emil RuusuvuoriClay | 6-4 7-5 | 3 | 85 | 1 | 0 | 71.7% | 67.4% | 76.5% | 1/2 |
| R16 | 2 | Carlos AlcarazClay | 25 | Roberto Bautista AgutClay | 6-3 7-5 | 3 | 113 | 3 | 3 | 56.0% | 61.9% | 54.5% | 4/7 |
| QF | 5 | Stefanos TsitsipasClay | 19 | Alex de MinaurClay | 6-4 6-2 | 3 | 81 | 1 | 0 | 56.9% | 72.4% | 72.7% | 1/1 |
| QF | 20 | Lorenzo MusettiClay | 8 | Jannik SinnerClay | W/O | 3 | 0 | - | - | - | - | - | - |
| QF | 26 | Daniel EvansClay | 32 | Francisco CerundoloClay | 2-6 7-5 6-3 | 3 | 130 | 2 | 3 | 57.5% | 58.0% | 54.1% | 8/13 |
| QF | 2 | Carlos AlcarazClay | 38 | Alejandro Davidovich FokinaClay | 7-6(5) 6-4 | 3 | 130 | 1 | 3 | 55.7% | 67.3% | 46.2% | 8/11 |
| SF | 5 | Stefanos TsitsipasClay | 20 | Lorenzo MusettiClay | 6-4 5-7 6-3 | 3 | 148 | 5 | 4 | 67.4% | 67.7% | 46.7% | 5/10 |
| SF | 2 | Carlos AlcarazClay | 26 | Daniel EvansClay | 6-2 6-2 | 3 | 80 | 4 | 0 | 64.7% | 69.7% | 55.6% | 3/4 |
| F | 2 | Carlos AlcarazClay | 5 | Stefanos TsitsipasClay | 6-3 6-4 | 3 | 78 | 3 | 1 | 77.1% | 81.1% | 72.7% | 1/2 |
