| 2021-11-28 | Davis Cup Finals RR: ESP vs RTF | Hard | RR | 107 |  Feliciano Lopez | 5 |  Andrey Rublev | 2-6 6-3 6-4 | H2H | 3 | 105 | 14 | 5 | 50.0% | 81.6% | 44.9% | 10/12 |
| 2021-11-26 | Davis Cup Finals RR: ESP vs ECU | Hard | RR | 106 | Feliciano Lopez | 291 |  Roberto Quiroz | 6-3 6-3 | H2H | 3 | 78 | 14 | 6 | 73.5% | 74.0% | 44.4% | 5/5 |
| 2021-10-04 | Indian Wells Masters | Hard | R128 | 60 |  Tommy Paul | 108 | Feliciano Lopez | 6-3 7-6(3) | H2H | 3 | 88 | 2 | 2 | 50.8% | 81.3% | 58.1% | 0/2 |
| 2021-08-30 | US Open | Hard | R128 | 116 | Bernabe Zapata Miralles (LL) | 97 | Feliciano Lopez | 5-7 7-6(6) 4-6 6-3 6-3 | H2H | 5 | 195 | 15 | 3 | 72.0% | 74.8% | 75.0% | 3/5 |
| 2021-08-23 | Winston-Salem | Hard | R64 | 133 |  Lucas Pouille (Q) | 97 | Feliciano Lopez | 6-1 6-4 | H2H | 3 | 70 | 9 | 2 | 57.4% | 82.9% | 50.0% | 4/4 |
| 2021-08-09 | Canada Masters | Hard | R32 | 49 |  Lloyd Harris | 97 | Feliciano Lopez (LL) | 6-2 6-3 | H2H | 3 | 64 | 11 | 2 | 74.5% | 84.2% | 53.8% | 3/3 |
| 2021-08-02 | Washington | Hard | R64 | 103 | Denis Kudla | 92 | Feliciano Lopez (WC) | 6-3 6-7(5) 6-3 | H2H | 3 | 140 | 12 | 4 | 52.7% | 72.4% | 67.3% | 6/6 |
| 2021-07-19 | Gstaad | Clay | R16 | 96 |  Mikael Ymer | 89 | Feliciano Lopez (8) | 6-7(6) 7-6(7) 6-4 | H2H | 3 | 145 | 7 | 5 | 71.7% | 74.4% | 50.0% | 5/6 |
| 2021-07-19 | Gstaad | Clay | R32 | 89 | Feliciano Lopez (8) | 162 |  Marc-Andrea Huesler | 6-4 4-6 6-5 RET | H2H | 3 | 126 | 8 | 6 | 49.5% | 75.6% | 58.7% | 4/7 |
| 2021-07-12 | Hamburg | Clay | R32 | 114 | Carlos Taberner (Q) | 90 | Feliciano Lopez | 6-4 3-6 6-3 | H2H | 3 | 129 | 4 | 3 | 69.4% | 79.7% | 57.7% | 4/5 |
